Composition: - Each capsule contains Vitamin B1 .....................10 mg. Vitamin B2 .....................10 mg. Vitamin B6 .......................3 mg. Nicotinamide ..................50 mg. Folic Acid ....................1000 mcg. Calcium Pantothenate .....10 mg. Vitamin B12 .....................5 mcg. Monohydrochloride ........150 mg. Description: - Vitamins are non energy producing organic compounds, essential for human metabolism, that must be supplied in small quantities in diet. The importance of Vitamins, as a drug is primarily in prevention and treatment of deficiency diseases and vitamins deficiency occurs due to in adequate in take, malabsorption, increased tissue needs, increased excretion, certain genetic abnormalities and drug vitamin interaction. However vibel forte contains all water-soluble vitamins. These are meagerly stored, excess is secreted with a little chance of toxicity. They all act as cofactors for specific enzymes of metabolism. The various components of vibel forte are as follows: (A) Thiamine Hydrochloride (Vitamin B1): The Thiamine is fundamentally associated with carbohydrate metabolism. By combining with the pyrophosphoric acid in nucleated cells particularly in the liver, kidneys and WBC, it is converted in the body to its pyrophosphate which acts as a coenzyme in some reactions as the decarboxylation of – ketoacid, hexos monophophate shunt. The outstanding example of its example of its effective use is in the treatment of beriberi in which there is a gross deficiency not only of thiamine but also of other factors of Vitamin B-Group. There is some evidence that neuritis associated with pregnancy and the neuritis of pellagra is attributable to thiamine deficiency. (B) Riboflavin 5 Phosphate (Vitamin B2): Riboflavin is inactive until phosphorylated flavine mononucleotide and flavine adenine dinucleotide are its active forms and these are involved as coenzymes in the respiratory chain and in oxidized phosphorylation. There is a little evidence that Riboflavin of therapeutic value expect in the treatment of ariboflavinosis . (C.) Pyridoxine Hydrochloride (Vitamin B6): Pyridoxine, pyridoxal, and pyridoxamine, with occurs in food stuff are collectively knaon as Vitamin B6 As a nutritional supplement it is usually employed in conjunction with other vitamins of B-Groups. (D) Niacinamide: Niacinamide produces improvement in the mental, dermal & alimentary manifestation of pellagra but neurological symptoms may need prolonged treatment and the concomitant use of other vitamins of B-Group. (E)It is component of coenzyme, which function in carbohydrate, fat, steroid and porphyrin metabolism. These all components are essential in our body metabolism and other necessary functions. Deficiency of which will cause a number of problems like dermatitis, diarrhoea dementia, dry scaly skin, loss of hair, anemia, and beriberi. There are many other malnutrition problems associated with vitamins deficiency, which may cause severe or mild problems. Indications: - 1) Treatment of Pellagra, hartnup’s disease, in peripheral vascular disease and as hypolipoproteinemic. 2) Also used prophylactically (2-10 mg daily) in infants, pregnant women, chronic diarrhoeas, and patients on parenteral alimentation. Glucose infusion unmasks marginal thiamine deficiency.