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 COMPOSITION
:
Each tablet contains
Renitidine HCl ……………150
mg.
Domperidone ……………..
10 mg.
DESCRIPTION:
This combination of Ranitidine & Domperidone
is higly effective in releaving nausea, vomiting,
dyspepsia & hyperacidity. In this combination
Domperidone is a potent dopamine antagonist with
antiemetic properties. It increases lower oesophageal
sphincter pressure, antral & duodenal contractions,
gastric emptying of liquids and semi-solids, and
shortens the stationary phase for solids in the
stomach. Ranitidine is an cimetidine derivative
and H2 receptor antagonist. It blocks
histamine induced gastric secretion , cardiac
stimulation, Uterine relaxation and bronchial
relaxation. They attenuate fall in BP due to histamine
.The only Significant in vivo action of H2
blockers is marked inhibition of gastric secretion.
The most Prominent action is on acid output, Pepsin
Content and intrinsic factor secretions are also
reduced. The ulcer healing doses produce 60-70%
inhibition of 24 hours acid output. Thus ranitidine
has relatively long duration of action and so
a single dose of 150 mg. effectively suppresses
gastric acid secretion for 12 hours. It also has
antiulcerogenic effect. Gastric ulceration due
to stress and drugs is prevented. So this combination
is highly effective in cases of emesis, nausea
& vomiting produced due to hyperacidity problems.
Indication :
· Symptomatic relief of acute nausea &
vomiting. Gastric motility disorders such as reflux
oesophagitis & duodenogastric dysptic sympotoms.
· It is used in conditions for suppressing
gastric acid secretion.
· Used for duodenal ulcer, Gastric ulcer
,Stress ulcer and gastritis.
· Used in stressful situations like hepatic,
severe burns and trauma.
· Zollinger Ellison syndrome, Gastro Oesophagel
reflux, Prophylaxis of aspiration Pneumonia and
has beneficial action in certain cases of Urticaria.
· It also relieves Postoperative Gastric
ulceration and other hyperacidity syndromes where
reduction of acidity is beneficial.
Contraindications: Hypersensitivity
reactions.
Pregnancy: Contraindicated
Lactation: Contraindicated
Paediatrics: Reduced dose necessary.
Elderly: Safe
Presentation: 10 x 10 strips
in one Multicarton.
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