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 Composition:
Each tablet contains:
Nimesulide ....100 mg.
Caffeine (anhydrous) 30 mg
Descrption: It is a newer NSAID
and is a sufonanilide derivative.It Exerts its
effect by reducing generation of superoxides by
neutrophils, inhibition of PAF synthesis and TNF
release, free radical scavenging. It has comparable
antipyretic and anti-inflammatory activity to
other NSAIDs.
It is analgesic and antipyretic in action, apart
from its anti-inflammatory action. Unlike other
NSAID’S, the chemical structure of Nimesulide
does not contain a carboxylic group but has sulfonanilide
moiety as the acidic group. It is absorbed rapidly
and completely after oral administration. It acts
by inhibiting the release of tumour necrosis factor-alpha,
acts as a competitive inhibitor of histamine release
and reduces superoxide anion formation. It has
better gastric tolerability than other NSAIDs.
Asthmic patients who develop bronchospasm or intolerance
to aspirin or other NSAIDs do not cross react
with nimesulide. It is better absorbed orally
in 99% plasma protein bound.
Caffeine has been widely used in analgesic preparations
to enhance the effect of both non-opioid &
opioid analgesic but is of debatable benefit.
It also stimulates CNS and gives a feeling of
well being with Nimesulide.
Indications: Rheumatoid arthritis,
osteoarthritis, other degenerative joint disorders,
musculoskeletal disorders, low back pain, dysmenorrhoea,
gynecological conditions, thrombophlebitis dental
pain and in ENT inflammations.
Contraindications: Hypersensitivity,
active peptic ulcer disease, hepatic impairment.
Special precautions: Active peptic
ulcer, elderly patients with moderate renal impairment,
congestive heart failure or cirrhosis.
Paediatrics: Reduced dose is
necessary.
Preganancy: Contraindicated.
Lactation: Use with caution.
Elderly: Use only, if clearly
indicated.
Side effects: Epigastric pain,
heart burn, nausea, diarrhoea, vomiting, skin
rash, prorates dizziness, somnolescence, headache.
Drug interactions: Displace methotrexate
from its binding sites, decrease the plasma level
of theophylline, oral bioavailability of frusemide
may be reduced, displaced by the concomitant use
of fenofibrate, salicylic acid, valproic acid.
Dosage: Adults: 1 tablet thrice
a day.
Presentation: 20x 12 Blister
strips in a Multicarton. |
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