Description: Norfloxacin is a most potent first generation flouroquinolone antimicrobial agent with potent activity against a broad spectrum of gram- positive and gram- negative bacteria including Ps. aeruginosa, Enterobacteriaceae and Staph. aureus.Norfloxacin does not disturb normal anaerobic intestinal flora and has significant post–antibiotic effect & thus prevents regrowth of bacteria.It has remarkable microbiological features like
· Rapid bactericidal activity and high potency.
· Relatively long post antibiotic effect on enterobacteriacea.
· Low frequency of mutational resistance.
· Low Propensity to select plasmid type resistant mutants.
· Active against many beta lactum and aminoglycoside resistant bacteria.
Indications: Norfloxacin is effective in broad range of infections .It has wide spectrum bactericidal activity. It is a drug of choice in
· Respipiratory tract infections, Urinary tract infections, E.N.T. , skin and soft tissue infections, conjunctivitis.
· Gastro intestinal tract infections, Intra abdominal infections, Gynaecological infections, meningitis.
· Infections in bone and joint and severe systematic infections.
· Gonorrohoea, chancroid,bacterial gastroenteritis
· Prophylaxis of sepsis in neutropenic patients.
Contraindications: Hypersensitivity to Norfloxacin or any other quinolone
Derivative . Not recommended for use in children and adolescents.
Paediatrics: Safety not established.
Pregnancy: Contraindicated.
Lactation: use only if clearly indicated.
Elderly: safe
Children: Not recommended
Dosage: 1 tablet twice a day
Presentation: 25x10 tablets in a Multicarton