Composition: Each tablet contains: Nimesulide: 100 mg Paracetamol: 500 mg Description: Neulab Active is a safe Combination of Nimesulide with paracetamol. Nimesulide is a newer NSAID and is a sulfonanilide derivative.It exerts its effect by reducing generation of superoxides by neutrophils, inhibition of PAF synthesis and TNF release, free radical scavenging, inhibition of metalloprotinase activity in cartilage. It is an analgesic and antipyretic in action, apart from its anti-inflammatory action. It is absorbed rapidly and completely after oral administration. It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation.It has better gastric tolerability than other NSAIDs. Asthmic patients who develop bronchospasm or intolerance to aspirin or other NSAIDs do not cross react with Nimesulide. It is better absorbed orally. 0 in 99% plasma protein bound. Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity. These effects are related to inhibition of prostaglandin synthesis. It raises pain threshold and is a good and promptly acting antipyretic. Paracetamol does not stimulate respiration or acid base balance and hence does not increase cellular metabolism. It is an analgesic- antipyretic of choice especially in patients in whom salicylates or other NSAIDs are contraindicated. Such cases include asthmatics. It also do not results in gastric irritation or mucosal erosion at therapeutic doses .So peptic ulcer patients and in whom salicylates are not used because of the risk Reye’s syndrome Paracetamol is a safe drug to use. Indications: Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders, musculoskeletal disorders, low back pain, dysmenorrhoea, gynecological conditions, thrombophlebitis dental pain and in ENT inflammations. In children: Fever & other sign and in RT inflammation. Children: 5mg/kg/day in 2 or 3 divided doses. Contraindications: Hypersensitivity, active peptic ulcer disease, hepatic impairment. Special precautions: Active peptic ulcer, elderly patients with moderate renal impairment, congestive heart failure or cirrhosis. Paediatrics: Reduced dose is necessary. Preganancy:Contraindicated. Lactation: Use with caution. Elderly :Use only, if clearly indicated. Side effects: Epigastric pain, heart burn, nausea, diarrhoea, vomiting, skin rash, prorates dizziness, somnolescence, headache. Drug interactions: Displace methotrexate from its binding sites, decrease the plasma level of theophylline, oral bioavailability of frusemide may be reduced, displaced by the concomitant use of fenofibrate, salicylic acid, valproic acid. Dosage: Adults : 100 mg twice daily. Presentation: 25x 10 Blister strips in a Multicarton.