DESCRIPTION:- Aspirin is acetylsalicylic acid with strong anti inflammatory, action & weaker analgesic action. It is one of the oldest analgesic anti -inflammatory drug. It is rapidly converted in the body to salicylic acid which is responsible for most of the action. It relives inflammatory, tissue injury related, connective tissue and integumental pain. The analgesic action is mainly due to obtunding of peripheral pain receptors and prevention of PG mediated sensitization of nerve endings. A central sub cortical action raising threshold to pain perception also contributes. No sedation, subjective effects, tolerance or physical dependence is produced. It also acts has anti platelet drug in small doses. Platelet activation is a key in acute arterial thrombosis. Small doses of aspirin block platelet aggregation by irreversible inhibition of the platelet enzyme cyclooxygenase, preventing formation of thromboxane A, a proaggregatroy vasoconstrictor at a dose of 50 – 100 mg. Daily. Caffeine is a CNS stimulant which produces a sense of well being, alertness, beats boredom, allays fatigue, improves performance & increases motor activity.
INDICATIONS:- Fradol Forte is used for headache, backache, jointpain, pulled muscle, toothache, fever, rheumatoid arthritis of osteoarthritis and allays fatigue & boredom associated with the above conditions producing a sense of well being & alertness.
CONTRAINDICATION:- Aspirin and Caffeine both are to be avoided in peptic ulcer patients. Hypersensitivity, hemophilia, hypoprothrombinaemia, platelet disorders and other bleeding disorders. Should be avoided in diabetics and in juvenile rheumatoid arthritis and should be stopped before surgery.
Paediatrics: Not recommended under 12 years.
Pregnancy: Contraindicated.
Lactation: Use with caution.
Elderly: No special problem.
PRESENTATIONS: 10 x 10 TABLETS IN MULTICORTON