Description: Oxytocin is an octapeptide secreted
by posterior pituitary along with ADH. It increases
the Force and frequency of uterine contractions. Estrogens
sensitize the uterus to oxytocin; nonpregnant uterus
and that during early pregnancy is rather resistant.
Oxytocin in high dose exerts an ADH like action.
Composition: - Each ml contains:
Oxytocin 10 I.U.
Indications: - Induction of labour, uterine inertia,
Post partum haemorrhage. Cesarean section. Abortion,
Breast engorgement.
Contraindications: - Hypertonic contractions,
Cephalopelvic disproportion, excessive distention
of the Uterus as in multiple pregnancies, hydramnious.
Hypersensitivity to the drug. Parity greater than,
elderly multivariate, previous caesarean section or
other surgery involving the uterus, severe toxemia,
predisposition to amniotic fluid.
Special Precautions: - Use only medical reasons rather
than for convenience.
Side effects: - Injudicious use of oxytocin
during labour can produce too strong urine contraction
forcing the presenting part through incompletely dilated
birth canal, causing maternal and foetal soft tissue
injury, rupture of uterus, foetal asphyxia and death.
Water intoxication, toxaemia of pregnancy and renal
insufficiency due to ADH like action.
Dosage: - Induction or enhancement of labour:
i.v. Drip infusion of a 5% dextrose soln. Containing
1 i.u oxytocin per 100 ml 3 rd. stage labour &
puerperium 5-10 i.u. i.m. Or 5 i.u. Slow IV. Caesarean
section: 5 i.u. After delivery.
Presentation: - Box of 20 x 6 x 1 ml ampoule
(Blister pack)
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