Description: Gentamicin is a
an aminoglycoside antibiotic, produced by Micromonospora
purpurea & available as Sulphate.Gentamicin
is effective against Pseudomonas, E-coil, Proteus,
A. aerogenes, K. Phenumonas, salmonellae &
group. Abetahemolytic streptococci, Staphylococci
are also highly sensitive including those resistant
to penicillin, neomycin & Kanamycin. The inhibitory
concentration of Gentamicin can produce a bactericidal
effect. Resistance develops slowly but cross-resistance
to Kanamycin & neomycin can occur.
Composition: Each ml contains
Gentamicin 40mg
as Gentamicin sulphate
INDICATIONS:
1). LOCAL INFECTION: Gentamicin
has been employed in a wide variety infected
skin lesions. It is useful in treating cases
of burns infected with pseudomonas, bed sore
& nasal carriers of staphylococci.
2). Systemic infections: Although
several gram-positive bacteria are susceptible
to gentamicin effectively, for treating infections
caused by these bacteria. Gentamicin along with
penicillin or pseudomonas aeruginosa, enterobactor,
klebsiella & serratia & by other species
resistant to less toxic antibiotic. The infections
so treated include Urinary Tract infections,
peritonitis, meningitis, osteomylitis septic
burns, otitis, pneumonia & bacteremia.
ADVERSE REACTION: Allergic
skin reactions & possibly photosensitivity
reaction have occurred. The parenteral therapy
particularly in the presence of renal impairment
may produce vestibular damage and ototoxicity.
Dizziness is the main presenting symptom.
Dosage: 3-5 mg/kg body weight
I.M. or I.V. daily in 3 divided doses
Presentation: 2ml vial of 40mg/ml
10ml vial of 40mg/ml
20ml vial of 40mg/ml
30ml vial of 40mg/ml
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