Composition: Each tablet contains: Nimesulide ...100 mg Description: It is a newer NSAID and is a sufonanilide derivative. It Exerts its effect by reducing generation of superoxides by neutrophils, inhibition of PAF synthesis and TNF release, free radical scavenging. It has comparable antipyretic and anti-inflammatory activity to other NSAIDs. It is an analgesic and antipyretic in action, apart from its anti-inflammatory action. Unlike other NSAID’S, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group. It is absorbed rapidly and completely after oral administration. It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation. It has better gastric tolerability than other NSAIDs. Asthmic patients who develop bronchospasm or intolerance to aspirin or other NSAIDs do not cross react with Nimesulide. It is better absorbed orally. Indications: Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders, musculoskeletal disorders, low back pain, dysmenorrhoea, gynecological conditions, thrombophlebitis dental pain and in ENT inflammations. Contraindications: Hypersensitivity, active peptic ulcer disease, hepatic impairment. Special precautions: Active peptic ulcer, elderly patients with moderate renal impairment, congestive heart failure or cirrhosis. Paediatrics: Reduced dose is necessary. Preganancy: Contraindicated. Laciation: Use with caution. Elderly : Use only, it clearly indicated. Side effects: Epigastric pain, heart burn, nauseas, diarrhoea, vomiting, skin rash, prorates dizziness, somnolescence, headache. Drug interactions: Displace methotrexate from its binding sites, decrease the plasma level of theophylline, oral bioavailability of frusemide may be reduced, displaced by the concomitant use of fenofibrate, salicylic acid, valproic acid. Dosage: Adults : 100 mg twice daily. Presentation: 25x 10 Blister strips in a Multicarton.