Description: Ciprofloxacin is a most potent first generation flouroquinolone antimicrobial agent with potent activity against a broad spectrum of gram- positive and gram- negative bacteria including Ps. aeruginosa, Enterobacteriaceae
and Staph. aureus. Ciprofloxacin does not disturb normal anaerobic intestinal flora and has significant post–antibiotic effect & thus prevents regrowth of bacteria.It has remarkable microbiological features like
· Rapid bactericidal activity and high potency.
· Relatively long post antibiotic effect on enterobacteriacea.
· Low frequency of mutational resistance.
· Low Propensity to select plasmid type resistant mutants.
· Active against many beta lactum and aminoglycoside resistant bacteria.
Indications: Ciprofloxacin is effective in broad range of infections .It has wide spectrum bactericidal activity. It is a drug of choice in
· Respipiratory tract infections, tuberculosis, Urinary tract infections, E.N.T. , skin and soft tissue infections, conjunctivitis.
· Gastro intestinal tract infections, Intra abdominal infections, Gynaecological infections, meningitis.
· Infections bones joint soft tissues and severe systematic infections.
· Gonorrohea, chancroid,bacterial gastroenteritis
· Ciprofloxacin is now first drug of choice in typhoid fever
Contraindications : Hypersensitivity to ciprofloxacin or any other quinolone
derivative . Not recommended for use in children and adolescents.
Paediatrics: Safety not established.
Pregnancy: Contraindicated.
Lactation: Drug passes into breast milk may affect the infant adversely.
Dosage: 250-750 mg twice in a day.
Presentation: Ceflox 250 mg as 20 x 10 tablets in a Multicarton.