 COMPOSITION:
-
Tetracycline……500 mg
DESCRIPTION: - This comes from
the class of antibiotics having a nucleus of four
cyclic rings. All are obtained from soil actinomycetes.
Tetracycline is primarily bacteriostatic; and
is classified in the third group of tetracyclines.
It is a semi synthetic antibiotic with high potency,
complete intestinal absorption, and high plasma
protein binding, with a plasma t ½ of 18-24
hrs. It has minimal effect on intestinal flora
and hence incidence of diarrhoea is low. It has
least renal toxicity and hence is a highly effective
Broad Spectrum Antibiotics. It inhibits protein
synthesis by binding to 30S ribosomes in susceptible
organism. Subsequent to such binding, attachment
of aminoacyl-tRNA to the mRNA- ribosome complex
is interfered. As a result the peptide chain fails
to grow. The sensitive organisms have an energy
dependent active transport process which concentrates
tetracycline intracellularly. In gram-negative
bacteria tetracycline diffuse through porin channels
as well. The more lipid soluble members (doxycycline,
minocycline) enter by passive diffusion also (this
is partly responsible for their higher potency).
The carrier involved in active transport of tetracycline
is absent in the host cells. Moreover, protein-synthesizing
apparatus of host cells is less sensitive to tetracycline.
These two factors are responsible for the selective
toxicity of tetracycline for the microbes.
INDICATIONS: -
§ It is used as a broad Spectrum
Antibiotic.
§ It is used in Respiratory, genito-urinary,
dental, and ophthalmic, ENT and gynecological
infections.
§ It is used in Chlamydial infections,
to treat atypical pneumonia due to Mycoplasma
pneumoniae, cholera, Brucellosis.
§ It is used in the treatment of Plague:
Tetracycline is highly effective in both bubonic
and pneumonic plague.
§ It is used inRelapsing fever due to Borrelia
recurrentis responds adequately.
§ It is used inReckettsial infections like
typhus Rocky Mountain spotted fever, Q fever
responds dramatically.
§ It may also be used in certain cases
of UTI.
CONTRAINDICATION: - Hypersensitivity.
SPECIAL PRECAUTIONS: - impaired
hepatic function, blood dyscrasias. Regular
blood counts on long term therapy, Antacids,
mineral supplements.
Paediatrics: Not recommended
under 8 years. In older children reduced dose
necessary.
Pregnancy: Contraindicated,
may discolour teeth of the foetus.
Lactation: Contraindicated.
Elderly: No know problem.
Side effects: Tooth discoloration,
enamel hypoplasia, reduced fibula growth rate.
Avoid use in children below 8 years, unless
no alternative drug.
Drug Interaction: Antacids,
milk, calcium, magnesium and iron reduce absorption.
PRESENTATION: -
Tetralab 500 mg: 10 X 10 CAPSULE IN ONE MULTICARTON
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