COMPOSITION: - Amoxicillin trihydrate Equivalent to Amoxicillin…………..250 mg Cloxacillin sodium ………………….250 mg DESCRIPTION: - Amoxicillin is semi-synthetic amino penicillin, an analogue of ampicillin, with a Good spectrum of bactericidal activity against many gram- positive and gram-negative microorganisms. Amoxycillin is stable in presence of gastric acid and may be given without regard to meals. It acts through inhibition of biosynthesis of cell wall mucopeptide and bacterial cell explodes due to internal pressure. Its oral absorption is better and has higher and more sustained blood levels. It has low incidences of diarrhea. It is active against shigella and H.Influenza.It is also more active against those microbes which are sensitive to PenicillinG; in addition many gram-negative bacilli like E.Colli, proteus, Salmonella are inhibited. Cloxacillin has an isoxazoly side chain and is highly penicillinase as well as acid resistant. It is more active than methicillin against penicillinase producing Staph. It absorbed from gut. A combination of Amoxicillin and Cloxacillin is clinically effective against a wide range of gram-positive and gram-negative organisms including penicilinase-producing bacteria. INDICATIONS: - § Respiratory Tract infections including Bronchitis, sinusitis, otitis media. § Urinary-urinary, skin and soft tissue infections. § ENT infections due to susceptible strains of Gram-negative organisms like. H.influenzae, E.coli, P.mirabilis and N.gonorrhoea.Gram positive organisms like streptococci (including streptococcus faecalis) D.pneumoniae and non-penicillase producing staphylococci. Contra-indications: - Individuals with a history of an allergic reaction to the penicillins. Paediatrics: Safe. Pregnancy: No evidence of risk. Lactation: safe. Elderly: No known problem. Dosages: one capsule thrice a day. PRESENTATION: - Available as 10 x 10 capsule in one multicarton.