DESCRIPTION: - It is Bacteriostatic, broad-spectrum antibiotic and is highly active against Salmonella including S.typhi. In high doses, it can inhibit mammalian mitochondrial protein synthesis as well. Bone marrow cells are especially susceptible. It has a nitrobenzene substitution, which is mostly responsible for its antibacterial activity and its intensely bitter taste. Chloramphenicol inhibits bacterial protein synthesis by interferring with `transfer’ of the elongating peptide chain to the newly attached aminoacyl tRNA at complex. It specifically attaches to the 50S ribosome and thus may hinder the access of aminoacy1-Trna to the acceptor site for amino acid incorporation. Probably by acting as a peptide analogue, it prevents formation of peptide bonds. It is primarily bacteriostatic, though its high concentration may have cidal effect on some bacteria. This Antibiotic is active against the same range of organisms (gram-positive and gram-negative bacteria, Chlamydia, Mycoplasma, Rickettsiae).

INDICATIONS: - Enteric fever (Typhoid & Para typhoid), H.influenzae meningitis, anaerobic infections, intraocular infections, Urinary tract infection, Conjunctivitis, external ear infections.
Dosage: 1-2 gm daily in 4 divided doses.
Children: 20-40-mg/kg-body wt daily in divided doses.
Contraindications: Hypersensitivity, Latter half of pregnancy, Lactation.
Special Precaution: Renal or hepatic impairment milk, antacids, mineral supplements, oral contraceptives.
Paediatrics: Not recommended under 8 years, Reduced dose is necessary in older children.
Pregnancy: Contraindicated.
Lactation: Contraindicated.
PRESENTATION: -
Labchlor 250 mg 20 x 10 Capsules in one multicarton.
Labchlor 500 mg 10 x 10 Capsules in one multicarton.